Few treatments have earned their reputation the way Rejuran has. Developed in South Korea by PharmaResearch and powered by polynucleotides extracted from wild salmon DNA, Rejuran has spent years quietly dominating the Korean aesthetic market before the rest of the world caught on. Today it’s discussed by dermatologists from Seoul to Singapore to Los Angeles, celebrated by celebrities, and backed by decades of clinical data in regenerative medicine.
But “Rejuran” is not a single product. It’s an expanding family of formulations — each one built on the same PN science, each one engineered for a specific skin layer, concern, or patient profile. If you’re searching for skin rejuvenation that works at a cellular level rather than simply masking ageing on the surface, this guide gives you the complete picture of every Rejuran formula currently available, how they work, and how to decide which one belongs in your treatment plan.
What Makes Rejuran Different From Other Skin Boosters?
Understanding this one distinction shapes everything else: Rejuran heals; most other boosters hydrate.
Standard HA skin boosters (Profhilo, Restylane Skinboosters, etc.) deliver hyaluronic acid into the dermis to attract water and plump the skin temporarily. They work on the surface. Rejuran takes a fundamentally different approach — it delivers polynucleotides (PN), which are DNA fragments that interact directly with your skin’s own repair mechanisms at a cellular level.
Once injected, PN molecules activate fibroblast cells (the skin’s collagen factories), reduce inflammation, support DNA repair in damaged skin cells, and strengthen the extracellular matrix. The result is not temporary plumping — it’s genuine skin regeneration that builds progressively over weeks and outlasts a simple hydration boost. Clinical studies confirm that Rejuran delivers a measurable increase in skin thickness, a doubling of skin elasticity compared to HA-only treatments, and lasting improvements in texture, barrier function, and radiance.
The reason salmon DNA is used rather than any other source? Salmon DNA shares approximately 97% genetic similarity with human DNA — an extraordinary degree of biocompatibility that allows the purified PN molecules to integrate with skin cells seamlessly and with minimal immune response. PharmaResearch’s patented DOT™ (DNA Optimising Technology) further refines the extraction to remove all proteins and allergens, leaving only the bioactive PN fragments.
For a deep dive into how this all works in practice, Rejuran: The Complete Guide to Korea’s Most Trusted Skin Healing Injection covers the full science behind the treatment.
The Full Rejuran Product Range: What Each Formula Does
Rejuran Healer — The Original, The Foundation
Everything started here. Rejuran Healer contains high-purity polynucleotide (PN) in a medium-viscosity gel formula, delivered via micro-injections distributed across the face and neck. It is the most versatile formulation in the range — effective across virtually all skin types, all age groups from the mid-20s onwards, and a wide range of skin concerns.
At its core, Rejuran Healer is a skin health treatment. It doesn’t add volume, it doesn’t plump dramatically, and it doesn’t change your facial structure. What it does is repair the internal environment of your dermis — strengthening the barrier, triggering collagen production, reducing inflammation, and enabling skin cells to regenerate more efficiently than they would naturally. The visible result is skin that looks cleaner, more even, more radiant, and genuinely healthier — not treated.
Best suited for: Early signs of ageing, dull or fatigued skin, weakened skin barrier, sun damage, fine lines, acne-prone skin, and anyone wanting a foundational Korean skincare treatment that improves skin health from within.
Typical course: 3–4 sessions spaced 3–4 weeks apart. Results last 6–12 months; maintenance every 4–6 months.
Rejuran I — Precision Treatment for the Eye Area
The “I” stands for eye, and this formulation is purpose-built for the most delicate skin on the face. Rejuran I uses a lower-viscosity, thinner PN formula compared to the standard Healer, which allows it to be safely injected into the periorbital zone without the heaviness, lumps, or papules that thicker injectables can cause in this anatomically sensitive area.
The skin around the eyes is thinner than anywhere else on the face and loses elasticity faster — which is why crow’s feet, under-eye crepiness, and fine periorbital lines appear earlier and are often more resistant to topical skincare. Rejuran I addresses this by delivering PN regeneration exactly where it’s needed: strengthening the thin dermis from within, improving the skin’s own collagen network, and over time softening lines and improving the appearance of dark circles through better microcirculation and skin thickness.
Clinical data supports it: wrinkle reduction around the eyes was observed in 94% of patients who completed four treatment sessions. It can be used on the same day as Rejuran Healer, with I targeting the periorbital zone while Healer covers the broader face.
Best suited for: Crow’s feet, fine under-eye lines, thin or crepey periorbital skin, and those whose primary aesthetic concern is the eye area.
Typical course: 3–4 monthly sessions; maintenance every 6–9 months. Each syringe is 1ml (vs 2ml for Healer).
For detailed before-and-after results from Rejuran in the under-eye area specifically, Rejuran Under Eye Results: What to Expect Before and After Treatment is the most informative next read.
Rejuran HB — Healing and Deep Hydration Combined
Rejuran HB (the HB stands for Hydro Booster) takes the standard Healer formula and adds two important components: high-molecular-weight hyaluronic acid (HA) and lidocaine. This makes it the most patient-friendly formulation in the range — noticeably more comfortable (lidocaine reduces procedure pain by approximately 53% compared to Healer) and delivering faster initial results due to the immediate hydration effect of the HA.
The PN and HA in Rejuran HB work in tandem rather than competing. HA binds water instantly and provides the immediate “glass skin” glow that patients notice within the first few days. Meanwhile, PN gets to work over the following weeks, stimulating collagen production and driving the deeper, longer-lasting biological repair that defines all Rejuran treatments. The effect is dual-layered: surface glow fast, dermal repair progressively.
Rejuran HB is particularly valuable for patients who are new to injectables and want both comfort and visible early results, and for those whose primary skin complaint is severe dryness, dehydration, or dullness — where the HA component delivers meaningful additional benefit beyond what PN alone would provide.
Best suited for: Chronically dry or dehydrated skin, patients sensitive to injection discomfort, those wanting earlier visible improvement, and first-time Rejuran patients.
Typical course: 3 sessions at 3–4 week intervals; maintenance every 6–9 months.
Rejuran Black — Premium Regeneration for Advanced Anti-Ageing
Rejuran Black represents the premium tier of the Rejuran range. It uses a highly purified, next-generation PDRN formulation — designated “Black Edition” to distinguish it from standard PN in terms of molecular purity and regenerative potency — combined with antioxidants and peptides that address the oxidative component of skin ageing alongside the collagen-stimulating and cellular repair mechanisms.
Where standard Rejuran Healer delivers foundational skin health improvement, Rejuran Black is designed for patients who need more: those dealing with visible signs of photoageing, uneven skin tone and pigmentation, or simply those who want the maximum regenerative impact the Rejuran science can deliver. The antioxidant complex helps neutralise the free radical damage that accumulates from years of sun exposure, pollution, and lifestyle factors — addressing ageing at both the cellular and oxidative levels simultaneously.
Rejuran Black has also attracted attention from patients in their 40s and 50s who previously assumed their skin had passed the point where non-invasive treatment could make a meaningful difference. The evidence from clinical use suggests otherwise — regenerative treatments like Rejuran Black often produce more noticeable improvements on aged or damaged skin than on young, already-healthy skin.
Best suited for: Patients with established photoageing, pigmentation concerns, oxidative skin damage, or those wanting maximum regenerative impact. Also appropriate as an intensive “skin reset” for patients in their 40s and 50s.
Typical course: 3 sessions at 4-week intervals; personalised maintenance.
Rejuran TrueSkin — High-Concentration Next-Generation Formula
Rejuran TrueSkin (TrueSkin Essence) is the most recent evolution of the Rejuran family, featuring a 2% polynucleotide concentration — higher than the original Healer formulation — combined with hyaluronic acid and four types of amino acids. This multi-component formula is clinically validated: studies show it improves skin hydration by 14.69% and elasticity by 21.78%, while stimulating collagen synthesis at a measurably higher rate than baseline.
The amino acid complex in TrueSkin is particularly notable — these are the building blocks that skin cells need for protein synthesis during the repair process. By combining PN (which signals the repair) with amino acids (which supply the raw material for it), Rejuran TrueSkin creates conditions for more efficient and comprehensive skin regeneration than PN alone.
A randomised, double-blind clinical trial comparing Rejuran TrueSkin to standard HA fillers found it superior in both wrinkle reduction and skin texture improvement. For patients dealing with scarring, acne damage, or simply wanting the highest-concentration, most complete polynucleotide treatment available, TrueSkin represents the current pinnacle of the Rejuran science.
Best suited for: Acne-damaged or scarred skin, advanced photoageing, patients who want the highest-potency polynucleotide treatment, and younger patients (from their 20s) pursuing intensive preventive care.
Typical course: 3 sessions, 4 weeks apart; maintenance every 6–9 months.
Quick Comparison: Which Rejuran Formula Fits Your Skin?
| Formula | Key Ingredients | Best For |
|---|---|---|
| Healer | PN (standard) | All-round skin health, barrier repair, general rejuvenation |
| I (Eye) | PN (lower viscosity) | Eye area — crow’s feet, thin periorbital skin, fine lines |
| HB | PN + HA + lidocaine | Dry / dehydrated skin, fast visible results, comfort-first |
| Black | Premium PDRN + antioxidants + peptides | Photoageing, pigmentation, oxidative damage, 40s–50s skin |
| TrueSkin | 2% PN + HA + amino acids | Scarring, high-concentration repair, intensive anti-ageing |
What the Treatment Process Actually Looks Like
Regardless of which Rejuran formula you receive, the treatment follows a broadly consistent structure.
Before the Session
A topical numbing cream is applied to the face for 20–30 minutes. For Rejuran HB, which already contains lidocaine, this reduces discomfort significantly before treatment even begins. In the week before your session, avoid aspirin, ibuprofen, fish oil, vitamin E supplements, and alcohol — all of which increase bruising risk.
The Injection Itself
Rejuran is delivered through a series of precise micro-injections into the superficial dermis, distributed evenly across the treatment area using serial puncture or mesotherapy-style technique. Sessions typically take 20–30 minutes. Small papules (bumps) at injection sites are expected — they indicate correct product placement and resolve within 24–48 hours.
Recovery
Mild redness, minor swelling, and occasional small bruises are the most common post-treatment side effects, usually settling within 2–3 days. Most patients resume normal activities the same day. Avoid saunas, intense exercise, alcohol, and direct sun exposure for 48–72 hours.
When You’ll See Results
- Week 1–2: Skin may feel softer and calmer; injection marks resolve
- Week 3–6: Noticeable improvements in texture, hydration, and early collagen formation
- Month 2–3: Fuller collagen remodelling visible — cleaner pores, firmer feel, improved tone and radiance
- After a complete course: Skin that looks genuinely healthier in a way that reads as natural, not treated
Combining Rejuran With Other Treatments
One of Rejuran’s practical advantages is how well it works alongside other aesthetic treatments. In Korean clinics, it’s routinely combined with:
- Laser resurfacing — Rejuran applied after laser accelerates healing and amplifies collagen results
- RF microneedling — the microchannels created by needling allow deeper PN penetration and synergistic collagen activation
- Botox — addresses muscle-driven dynamic wrinkles; Rejuran addresses skin quality. Complementary, not competing
- Juvelook — the increasingly popular “Rejuvelook” protocol layers Rejuran (for dermal skin health) with Juvelook (for deeper collagen biostimulation), delivering comprehensive rejuvenation across multiple tissue layers simultaneously
When combining treatments, always allow your practitioner to space them appropriately based on your skin’s response and recovery. Combinations are a nuanced clinical decision, not a one-size approach.
Is Rejuran Right for Your Skin? Who Benefits Most
Rejuran works across a remarkably broad patient spectrum — one of the reasons it’s become Korea’s number one injectable. It is effective for:
- ✔️ Adults from their mid-20s onwards — including as a preventive treatment for those who want to maintain skin quality before significant ageing occurs
- ✔️ Those with sensitive or reactive skin that doesn’t tolerate aggressive treatments
- ✔️ Patients with acne-damaged, sun-damaged, or barrier-compromised skin
- ✔️ Those wanting gradual, natural-looking improvement rather than dramatic structural change
- ✔️ Post-procedure patients wanting to accelerate healing after laser, peels, or microneedling
- ✔️ Anyone pursuing authentic Korean skincare — that is, skin health over aesthetic alteration
Rejuran is not suitable for pregnant or breastfeeding women, those with active skin infections in the treatment area, or patients with certain autoimmune conditions. Always disclose your full medical history to your practitioner before treatment.
For a neutral scientific reference on polynucleotides and their documented role in human biology and regenerative medicine, the Wikipedia article on polynucleotides is a reliable starting point.
The Bottom Line: Choosing Your Rejuran Formula
The right Rejuran formula is the one that matches your skin’s current state and your primary treatment goal:
- Want foundational skin health improvement? → Rejuran Healer
- Focused on the eye area? → Rejuran I
- Dry skin or first-time patient wanting comfort + fast glow? → Rejuran HB
- Dealing with photoageing, pigmentation, or oxidative damage? → Rejuran Black
- Want the highest-concentration repair formula for scars or intensive anti-ageing? → Rejuran TrueSkin
Whatever you choose, the underlying principle is the same: Rejuran works with your skin’s own biology, using science derived from decades of regenerative medicine research to help your skin do more of what it was always capable of — healing, rebuilding, and renewing from within. That’s what sets it apart from the crowded world of skin boosters and fillers, and that’s why it’s remained Korea’s number one injectable for years.
Disclaimer: This post is for informational purposes only and does not constitute medical advice. Always consult a qualified medical professional before undergoing any injectable treatment.
